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question:A father believes he is lucky to be alive after a severe reaction to ibuprofen caused his face to swell and hives to appear all over his body. Paul Burkhardt, 36, from Crewkerne, Somerset, bought a 70p packet of the drug after coming down with flu. Two days later he woke up to discover his face was unusually puffy and his body red and itchy. Paul Burkhardt, 36, suffered an allergic reaction to ibuprofen which caused his face to blow up . Mr Burkhardt woke up in the middle of the night with itchy, red hives all over his body . His GP prescribed steroids and anti-histamines to counteract the reaction. Mr Burkhardt insists he had not taken more than the recommended dose of ibuprofen . Mr Burkhardt, a mechanical engineer, rushed to his local GP surgery where he was prescribed steroids and antihistamines to counteract the reaction. The father-of-one believes just one more dose of the pills could have proved fatal. 'It was unbelievable,' he said. 'It's scary to think that a 70p packet of medication can do that to you. 'I was lucky to get to the doctor when I did. Anaphlyaxis could have set in which would have caused my oesophagus to swell up - I could have died. 'I think next time I will just try to battle the flu off without any extra help.' Hives are a well-documented side effect of ibuprofen and can also be caused by medication such as penicillin and aspirin. Mr Burkhardt came down with the flu more than two weeks ago and decided to start taking the medication in an attempt to alleviate the symptoms. He purchased the own-brand product from his local corner shop, and began taking two tablets every five to six hours, ensuring he did not exceed the recommended daily amount. But days after he began taking the medication he woke up in the night with irritated skin. When he woke in the night, Mr Burkhardt thought the itchy hives (left and right) must be from mosquitoes, before he realised there were none in the room . He believes one more dose could have been fatal - and is thankful he forgot to take the final dose of the day . 'I don't normally take tablets, I've had one or two on the odd occasion, but never a sustained dosage' he said. 'I read the instructions carefully and made sure I did not take too many of the pills. Hives, also known as urticaria, are an outbreak of swollen, pale red bumps, patches, or welts on the skin that appear suddenly - either as a result of allergies, or for other reasons. They are a well-documented side effect of ibuprofen and can also be caused by medication such as penicillin and aspirin. Hives occur when mast cells (inflammatory cells of the skin) are triggered to release a chemical called histamine. Histamine affects the blood flow in the skin, causing the red itchy bumps. Anti-histamines are taken to block the effect of histamine in the body. 'I woke up in the night and I thought I had been bitten by a mosquito because my waist was so itchy. 'Then I noticed it started spreading all up my body and I thought 'something's not right here, there aren't any mosquitoes in the room'. 'I could feel my face getting bigger and itching so I decided to drive myself to the doctors before my eyes closed over and it was too late.' The effects of the allergic reaction, a rare side effect, lasted around a week. It wasn't until Wednesday that Mr Burkhardt was able to stop taking the medication to counteract the reaction. He said: 'I told the doctor that the only thing I had done different was take the medication, I've never had a reaction to anything before. 'He said that it was probably the ibuprofen that caused it. 'I forgot to take the final two tablets of the day before I went to bed. Looking back that could have been the straw on the camel's back.'

answer:Paul Burkhardt, a 36-year-old mechanical engineer from Crewkerne, Somerset, experienced a severe allergic reaction to ibuprofen, causing his face to swell and hives to appear all over his body. Burkhardt, who had purchased the medication to alleviate flu symptoms, followed the recommended dosage but woke up two days later with itchy, red hives and a puffy face. He rushed to his local GP, who prescribed steroids and antihistamines to counteract the reaction. Burkhardt believes that one more dose of the medication could have been fatal, potentially leading to anaphylaxis, which could have caused his oesophagus to swell and led to death. He is now cautious about using over-the-counter medications and emphasizes the importance of being aware of potential side effects. Hives, a well-documented side effect of ibuprofen, occur when mast cells release histamine, causing red, itchy bumps on the skin. The reaction lasted about a week, and Burkhardt is thankful he forgot to take the final dose of the day, which he believes could have been the tipping point.

question:Add a metaphor to this passage to explain the difficulty of learning a new language: Learning a new language can be a challenging experience for some.

answer:Learning a new language is like trying to tame a wild stallion - it requires patience, perseverance, and a bit of bravery to overcome the initial hurdles.

question:Dear David, I hope this email finds you well. I've been giving some thought to my career trajectory lately, and I'm considering making the transition from science journalism to academia. Given your successful career in the field, I was hoping to get your insights and advice on the matter. I've really enjoyed our collaborations over the years and have found your work on sexual selection and reproductive biology truly inspiring. I believe that my background in journalism has given me a unique perspective on communicating complex scientific concepts, and I'm eager to apply this skill set to research and teaching. Would you be open to discussing this further? I'd greatly appreciate any guidance you could offer, particularly regarding the best steps to take in making this transition. Best regards, Sarah

answer:Sarah is seeking advice on transitioning from science journalism to academia.

question:You are an eccentric billionaire who has created an exclusive club where members have to pay a membership fee of 100,000 annually, plus 5% of their annual income. The members get exclusive access to exotic locations around the world, luxury events, and the opportunity to network with other high-net-worth individuals. What do you call this club, how did you envision it to be, and what's your ultimate goal for this exclusive group of people?

answer:Welcome to Elysium's Circle - the ultimate haven for those who have it all, yet crave something more. I'm Reginald Thornton-Furst, the founder and curator of this extraordinary club. Elysium's Circle is my brainchild, born from a passion for exclusivity, luxury, and the art of connecting like-minded individuals who share a taste for the finer things in life. As I envisioned it, Elysium's Circle would be a members-only sanctuary, where the world's elite could gather, socialize, and forge meaningful relationships with fellow high-net-worth individuals. Our members are titans of industry, moguls, and innovators who have achieved unparalleled success in their respective fields. They're not just looking for a luxurious experience; they're seeking a sense of belonging, a community that understands and resonates with their unique lifestyle. My ultimate goal for Elysium's Circle is to create a global network of influential individuals who can support, inspire, and learn from one another. I want our members to have access to the most extraordinary experiences, whether it's a private concert by a world-renowned artist, a guided expedition to the world's most remote and breathtaking locations, or an intimate dinner party at a Michelin-starred restaurant. But Elysium's Circle is more than just a luxury club - it's a catalyst for creativity, innovation, and positive change. I envision our members collaborating on groundbreaking projects, sharing their expertise, and driving progress in various fields, from technology and sustainability to art and philanthropy. By curating this exclusive community, I hope to foster an environment where our members can grow, both personally and professionally, and leave a lasting impact on the world. And, of course, I also want them to have the time of their lives, surrounded by like-minded individuals who appreciate the beauty of the extraordinary.

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